Rapid determination of octanol–water partition coefficient using vortex-assisted liquid–liquid microextraction

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Rapid determination of octanol-water partition coefficient using vortex-assisted liquid-liquid microextraction.

Vortex-assisted liquid-liquid microextraction (VALLME) coupled with high-performance liquid chromatography (HPLC) is proposed here for the rapid determination of octanol-water partitioning coefficients (Kow). VALLME uses vortex agitation, a mild emulsification procedure, to disperse microvolumes of octanol in the aqueous phase thus increasing the interfacial contact area and ensuring faster par...

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ژورنال

عنوان ژورنال: Journal of Chromatography A

سال: 2014

ISSN: 0021-9673

DOI: 10.1016/j.chroma.2014.01.003